Structural highlights
4res is a 6 chain structure with sequence from Sus scrofa. This structure supersedes the now removed PDB entry 3n2f. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , , , , |
| NonStd Res: | |
| Related: | 4hyt, 3n23, 4ret |
| Activity: | Sodium/potassium-exchanging ATPase, with EC number 3.6.3.9 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[AT1A1_PIG] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. [AT1B1_PIG] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.