4mak
Crystal structure of a putative ssRNA endonuclease Cas2, CRISPR adaptation protein from E.coliCrystal structure of a putative ssRNA endonuclease Cas2, CRISPR adaptation protein from E.coli
FunctionFunction
[CAS2_ECOLI] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).[1]
About this StructureAbout this Structure
4mak is a 2 chain structure with sequence from Escherichia coli str. k-12 substr. mg1655. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Perez-Rodriguez R, Haitjema C, Huang Q, Nam KH, Bernardis S, Ke A, DeLisa MP. Envelope stress is a trigger of CRISPR RNA-mediated DNA silencing in Escherichia coli. Mol Microbiol. 2011 Feb;79(3):584-99. doi: 10.1111/j.1365-2958.2010.07482.x. Epub, 2010 Dec 13. PMID:21255106 doi:10.1111/j.1365-2958.2010.07482.x