2x78

Human foamy virus integrase - catalytic core.Human foamy virus integrase - catalytic core.

Structural highlights 2x78 is a 3 chain structure with sequence from Human spumaretrovirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 2x6n, 2x6s, 2x74 Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Retroviral integrases are vital enzymes in the viral life cycle and thus are important targets for antiretroviral drugs. The structure of the catalytic core domain of the integrase from human foamy virus, which is related to HIV-1, has been solved. The structure of the protein is presented in two different crystal forms, each containing several molecules in the asymmetric unit, with and without the essential manganese or magnesium ion, and the structures are compared in detail. This allows regions of high structural variability to be pinpointed, as well as the effect of divalent cations on the conformation of the catalytic site. Structural studies of the catalytic core of the primate foamy virus (PFV-1) integrase.,Rety S, Reaeabkova L, Dubanchet B, Silhan J, Legrand P, Lewit-Bentley A Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Aug 1;66(Pt, 8):881-6. Epub 2010 Jul 27. PMID:20693659 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Retroviral Integrase

spinqualitylabelsall models 2x78, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image