3wi0
P453H/I471T mutant of PB2 middle domain from influenza virus A/Puerto Rico/8/34(H1N1)P453H/I471T mutant of PB2 middle domain from influenza virus A/Puerto Rico/8/34(H1N1)
Template:ABSTRACT PUBMED 24312396
FunctionFunction
[PB2_I34A1] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
About this StructureAbout this Structure
3wi0 is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Tsurumura T, Qiu H, Yoshida T, Tsumori Y, Hatakeyama D, Kuzuhara T, Tsuge H. Conformational Polymorphism of m(7)GTP in Crystal Structure of the PB2 Middle Domain from Human Influenza A Virus. PLoS One. 2013 Nov 29;8(11):e82020. doi: 10.1371/journal.pone.0082020. PMID:24312396 doi:http://dx.doi.org/10.1371/journal.pone.0082020