3o88
Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitorCrystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor
FunctionFunction
[AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
About this StructureAbout this Structure
3o88 is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Eidam O, Romagnoli C, Caselli E, Babaoglu K, Pohlhaus DT, Karpiak J, Bonnet R, Shoichet BK, Prati F. Design, Synthesis, Crystal Structures, and Antimicrobial Activity of Sulfonamide Boronic Acids as beta-Lactamase Inhibitors. J Med Chem. 2010 Oct 14. PMID:20945905 doi:10.1021/jm101015z