3moh

The structure of rat cytosolic PEPCK mutant A467G in complex with phosphoglycolate and GDPThe structure of rat cytosolic PEPCK mutant A467G in complex with phosphoglycolate and GDP

Template:ABSTRACT PUBMED 20476774

FunctionFunction

[PCKGC_RAT] Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

About this StructureAbout this Structure

3moh is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Johnson TA, Holyoak T. Increasing the conformational entropy of the Omega-loop lid domain in PEPCK impairs catalysis and decreases catalytic fidelity. Biochemistry. 2010 May 17. PMID:20476774 doi:10.1021/bi100399e

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OCA

[1] Johnson TA, Holyoak T. Increasing the conformational entropy of the Omega-loop lid domain in PEPCK impairs catalysis and decreases catalytic fidelity. Biochemistry. 2010 May 17. PMID:20476774 doi:10.1021/bi100399e

[xtra 1]