3ncc

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Template:STRUCTURE 3ncc

A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptorA human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor

Template:ABSTRACT PUBMED 20889499

FunctionFunction

[PRL_HUMAN] Prolactin acts primarily on the mammary gland by promoting lactation. [PRLR_HUMAN] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.[1]

About this StructureAbout this Structure

3ncc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Kulkarni MV, Tettamanzi MC, Murphy JW, Keeler C, Myszka DG, Chayen NE, Lolis EJ, Hodsdon ME. Two independent histidines, one in human prolactin and one in its receptor, are critical for pH dependent receptor recognition and activation. J Biol Chem. 2010 Sep 30. PMID:20889499 doi:10.1074/jbc.M110.172072
  1. ↑ Trott JF, Hovey RC, Koduri S, Vonderhaar BK. Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein. J Mol Endocrinol. 2003 Feb;30(1):31-47. PMID:12580759

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