3mpx
Crystal structure of the DH and PH-1 domains of human FGD5Crystal structure of the DH and PH-1 domains of human FGD5
FunctionFunction
[FGD5_HUMAN] Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
About this StructureAbout this Structure
3mpx is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.