2obo
Structure of HEPATITIS C VIRAL NS3 protease domain complexed with NS4A peptide and ketoamide SCH476776Structure of HEPATITIS C VIRAL NS3 protease domain complexed with NS4A peptide and ketoamide SCH476776
Template:ABSTRACT PUBMED 17444623
About this StructureAbout this Structure
2obo is a 4 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J Jr, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG, Madison V. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl] - 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization. J Med Chem. 2007 May 17;50(10):2310-8. Epub 2007 Apr 20. PMID:17444623 doi:10.1021/jm060173k
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OCACategories:
- Hepatitis c virus
- Arasappan, A.
- Bennett, F.
- Beyer, B M.
- Bogen, S F.
- Chen, K.
- Fischmann, T.
- Girijavallabhan, V.
- Guo, Z.
- Hong, Z.
- Ingram, R.
- Jao, E.
- Liu, Y.
- Love, R G.
- Madison, V.
- Malcolm, B.
- Myers, J.
- Njoroge, F G.
- Pichardo, J.
- Prongay, A J.
- Prosise, W W.
- Ramanathan, L.
- Saksena, A K.
- Senior, M.
- Strickland, C.
- Taremi, S S.
- Venkatraman, S.
- Weber, P C.
- Yang, R.
- Yao, N.
- Yarosh-Tomaine, T.
- Zhang, R.
- Hydrolase-hydrolase inhibitor complex
- Ketoamide inhibitor
- Viral protein