Interferon regulatory factor

Interferon regulatory factor (IRF) regulate transcription of interferons. IRF-1 functions as a transcriptional activator by binding to an interferon-stimulated response element in the gene promoter. IRF-3 and IRF-7 are activated by viruses or after binding to Toll-like receptors. IRF-4 is lymphoid-specific and functions in the development of immune cells. 3D structures of interferon regulatory factor Interferon regulatory factor 1 1if1 - mIRF DNA binding domain + DNA – mouse Interferon regulatory factor 2 1irf, 1irg – mIRF DNA binding domain – NMR 2irf - mIRF DNA binding domain + DNA Interferon regulatory factor 3 1qwt, 1j2f – mIRF 3a77 – hIRF DNA binding domain 3qu6 - hIRF DNA binding domain (mutant) 1t2k - hIRF DNA binding domain + interferon B enhancer + transcription factor AP-1 + DNA – human 2o6g - hIRF DNA binding domain + interferon B enhancer 2pi0 - hIRF DNA binding domain + interferon B promoter 1zoq – hIRF + CREB-binding protein 2o61 – hIRF3/IRF7/transcription factor + nuclear factor + DNA Interferon regulatory factor 4 2dll – hIRF IRF domain - NMR Interferon regulatory factor 5 3dsh – hIRF IRF domain (mutant) Interferon regulatory factor 7 3qu3 - mIRF DNA binding domain

spinqualitylabelsall models Structure of mouse interferon regulatory factor DNA-binding domain dimer complex with DNA (PDB entry 1if1) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image