1mf7
INTEGRIN ALPHA M I DOMAININTEGRIN ALPHA M I DOMAIN
Template:ABSTRACT PUBMED 12611591
DiseaseDisease
[ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
FunctionFunction
[ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
About this StructureAbout this Structure
1mf7 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ McCleverty CJ, Liddington RC. Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies. Biochem J. 2003 May 15;372(Pt 1):121-7. PMID:12611591 doi:http://dx.doi.org/10.1042/BJ20021273