1b6z
6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE
Template:ABSTRACT PUBMED 10024455
DiseaseDisease
[PTPS_RAT] Note=Deficiency leads to phenylketonuria.
FunctionFunction
[PTPS_RAT] Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
About this StructureAbout this Structure
1b6z is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Ploom T, Thony B, Yim J, Lee S, Nar H, Leimbacher W, Richardson J, Huber R, Auerbach G. Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase. J Mol Biol. 1999 Feb 26;286(3):851-60. PMID:10024455 doi:10.1006/jmbi.1998.2511