4jrg

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Template:STRUCTURE 4jrg

The 1.9A crystal structure of humanized Xenopus MDM2 with RO5313109 - a pyrrolidine MDM2 inhibitorThe 1.9A crystal structure of humanized Xenopus MDM2 with RO5313109 - a pyrrolidine MDM2 inhibitor

Template:ABSTRACT PUBMED 23808545

FunctionFunction

[MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).

About this StructureAbout this Structure

4jrg is a 2 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Ding Q, Zhang Z, Liu JJ, Jiang N, Zhang J, Ross TM, Chu XJ, Bartkovitz D, Podlaski F, Janson C, Tovar C, Filipovic ZM, Higgins B, Glenn K, Packman K, Vassilev LT, Graves B. Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development. J Med Chem. 2013 Jul 16. PMID:23808545 doi:10.1021/jm400487c

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