1h23
STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(12)-HUPYRIDONE AT 2.15A RESOLUTIONSTRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH (S,S)-(-)-BIS(12)-HUPYRIDONE AT 2.15A RESOLUTION
Template:ABSTRACT PUBMED 12517147
About this StructureAbout this Structure
1h23 is a 1 chain structure with sequence from Torpedo californica. Full crystallographic information is available from OCA.
See AlsoSee Also
- AChE bivalent inhibitors
- Acetylcholinesterase
- Torpedo Californica Acetylcholinesterase in complex with an (R)-Tacrine-(10)-Hupyridone inhibitor
- User:Dawn M. Wong
ReferenceReference
- ↑ Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL. Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity. J Am Chem Soc. 2003 Jan 15;125(2):363-73. PMID:12517147 doi:http://dx.doi.org/10.1021/ja021111w
- ↑ Carlier PR, Du DM, Han YF, Liu J, Perola E, Williams ID, Pang YP. Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product This work was supported by the Research Grants Council of Hong Kong (HKUST6156/97M), the Biotechnology Research Institute (HKUST), the Mayo Foundation, and the Istituto Pasteur Fondazione Cenci Bolognetti (E.P.). We thank Prof. X. C. Tang (Shanghai Institute of Materia Medica) for a gift of (-)-1. Angew Chem Int Ed Engl. 2000 May 15;39(10):1775-1777. PMID:10934357
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OCACategories:
- Acetylcholinesterase
- Torpedo californica
- Carlier, P R.
- Greenblatt, H M.
- Han, Y F.
- Pang, Y P.
- Silman, I.
- Sussman, J L.
- Wong, D M.
- Alzheimer's disease
- Bivalent ligand
- Dual-site binding
- Glycoprotein
- Gpi-anchor neurotransmitter degradation
- Huperzine some
- Hydrolase
- Inhibitor
- Membrane
- Muscle
- Nerve
- Neurotransmitter cleavage
- Serine esterase synapse
- Serine hydrolase