Catabolite control protein

<StructureSection load='2fep' size='350' side='right' caption='Structure of catabolite control protein (grey) complex with Hpr (khaki) and sulfate (PDB entry 2fep)' scene=>

Catabolite control protein (CcpA) is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins Hpr or Crh which interact with CcpA. The latter binds to DNA operator to modulate transcription.

3D structures of catabolite control protein3D structures of catabolite control protein

Updated on 01-December-2013

2jcg, 2hsg - BmCcpA – Bacillus megaterium
1sxg, 1sxh, 1sxi – BmCcpA (mutant)
2o20 - CcpA (mutant) – Streptococcus lactis

CcpA binary complexCcpA binary complex

2oen - BmCcpA + phosphocarrier protein Hpr
2fep - BsCcpA + phosphocarrier protein Hpr – Bacillus subtilis

CcpA ternary complexCcpA ternary complex

1rzr – BmCcpA + phosphocarrier protein Hpr + DNA
2nzu - BmCcpA + phosphocarrier protein Hpr + glucose-6-phosphate
2nzv - BmCcpA + phosphocarrier protein Hpr + fructose-1,6-diphosphate
1zvv – BsCcpA + catabolite repression Crh + DNA
3oqm, 3oqn, 3oqo - BsCcpA + phosphocarrier protein Hpr + DNA