2q1q
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
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OverviewOverview
Sulthiame, a clinically used antiepileptic, was investigated for its, interaction with 12 catalytically active mammalian carbonic anhydrase (CA, EC 4.2.1.1) isoforms. The drug is a potent inhibitor of CA II, VII, IX, and XII (K(I)s of 6-56nM), and a medium potency inhibitor against CA IV, VA, VB, and VI (K(I)s of 81-134nM). The high resolution crystal structure, of the hCA II-sulthiame adduct revealed a large number of favorable, interactions between the drug and the enzyme which explain its strong low, nanomolar affinity for this isoform and may also be exploited for the, design of effective inhibitors incorporating sultam moieties.
About this StructureAbout this Structure
2Q1Q is a Single protein structure of sequence from [1] with , and as ligands. Active as Carbonate dehydratase, with EC number 4.2.1.1 Full crystallographic information is available from OCA.
ReferenceReference
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: Kinetic and X-ray crystallographic studies., Temperini C, Innocenti A, Mastrolorenzo A, Scozzafava A, Supuran CT, Bioorg Med Chem Lett. 2007 Sep 1;17(17):4866-72. Epub 2007 Jun 14. PMID:17588751
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