2ojj
Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide
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OverviewOverview
The Ras/Raf/MEK/ERK signal transduction is a key oncogenic pathway, implicated in a variety of human cancers. We have identified a novel, series of pyrazolylpyrroles as inhibitors of ERK. Aided by the discovery, of two distinct binding modes for the pyrazolylpyrrole scaffold, structure-guided optimization culminated in the discovery of 6p, a potent, and selective inhibitor of ERK.
DiseaseDisease
Known diseases associated with this structure: Epileptic encephalopathy, Lennox-Gastaut type OMIM:[602897]
About this StructureAbout this Structure
2OJJ is a Single protein structure of sequence from Homo sapiens with SO4 and 82A as ligands. Active as Mitogen-activated protein kinase, with EC number 2.7.11.24 Full crystallographic information is available from OCA.
ReferenceReference
Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors., Aronov AM, Baker C, Bemis GW, Cao J, Chen G, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Martinez-Botella G, Namchuk MN, Straub J, Tang Q, Xie X, J Med Chem. 2007 Mar 22;50(6):1280-7. Epub 2007 Feb 15. PMID:17300186
Page seeded by OCA on Mon Nov 12 23:12:09 2007