2hn7
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HLA-A*1101 in complex with HBV peptide homologue
OverviewOverview
A high-resolution structure of the human MHC-I molecule HLA-A*1101 is, presented in which it forms a complex with a sequence homologue of a, peptide that occurs naturally in hepatitis B virus DNA polymerase. The, sequence of the bound peptide is AIMPARFYPK, while that of the, corresponding natural peptide is LIMPARFYPK. The peptide does not make, efficient use of the middle E pocket for binding, which leads to a rather, superficial and exposed binding mode for the central peptide residues., Despite this, the peptide binds with high affinity (IC50 of 31 nM).
DiseaseDisease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this StructureAbout this Structure
2HN7 is a Protein complex structure of sequences from Homo sapiens with SO4 as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue., Blicher T, Kastrup JS, Pedersen LO, Buus S, Gajhede M, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1179-84. Epub 2006 Nov 4. PMID:17142892
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