Fibroblast growth factor receptor

Fibroblast growth factor receptors (FGFR) are receptors which bind fibroblast growth factors (FGF). FGFR consist of an extracellular ligand-binding domain (LBD), transmembrane helix domain and cytoplasmic tyrosine kinase activity domain (TKD) with phosphorylated tyrosine designated PTR. FGFR LBD contains 3 immunoglobulin-like domains D1, D2 and D3. Each FGFR can activate several FGFs. Five FGFRs have been identified so far. FGFRs differ in their ligand specificity and tissue distribution. The binding of FGF to FGFR starts a cascade of signaling which influences mitogenesis and differentiation.

3D structures of fibroblast growth factor receptor3D structures of fibroblast growth factor receptor

Updated on 05-May-2013

FGFR1FGFR1

FGFR1 tyrosine kinase domain

1fgk, 3kxx, 3ky2 – hFGFR1 TKD (mutant) - human
1agw, 1fgi, 2fgi, 3c4f, 3js2, 3rhx, 4f63, 4f64, 4f65, 3tt0 – hFGFR1 TKD (mutant) + inhibitor
3krj – hFGFR1 TKD residues 538-678, 753-922 (mutant) + inhibitor
1xr0 – hFGFR1 residues 409-430 + FGFR signaling adaptor N terminal - NMR
3gqi – hFGFR1 TKD (mutant) with PTR + ACP
3gql – hFGFR1 TKD (mutant) + substrate

FGFR1 ligand-binding domain

2cr3 – hFGFR1 LBD D1 - NMR
2ckn – FGFR1 LBD D1 – mouse - NMR

FGFR1 complex with FGF

3ojv – hFGFR1 LBD D2,D3 (mutant) + hFGF1 - human
1cvs – hFGFR1 LBD D2,D3 (mutant) + hFGF2 (mutant)
1evt – hFGFR1 LBD D2,D3 + hFGF1
1fq9 – hFGFR1 (mutant) LBD D2,D3 + hFGF2 (mutant) + HS

FGFR2FGFR2

FGFR2 tyrosine kinase domain

1gjo, 1oec, 2psq – hFGFR2 TKD
2pvy, 2pwl, 2py3, 2pz5, 2pzp, 2pzr, 2q0b – hFGFR2 TKD (mutant) + ACP
3b2t – hFGFR2 TKD (mutant) + adenosine derivative
2pvf – hFGFR2 TKD with PTR + ACP + substrate peptide
3cly – hFGFR2 TKD (mutant) with PTR + ACP
3ri1 – hFGFR2 TKD + inhibitor

FGFR2 ligand-binding domain

3dar, 3caf, 3euu – hFGFR2 LBD D2
4hwu – hFGFR2 LBD D1

FGFR2 complex with FGF

1e0o – hFGFR2 (mutant) LBD D2,D3 + hFGF1 (mutant) + HS
3oj2, 3ojm – hFGFR2 (mutant) LBD D2,D3 + hFGF1
1djs – hFGFR2 LBD D2,D3 (mutant) + hFGF1
1ev2, 1ii4, 1iil – hFGFR2 LBD D2,D3 + hFGF2 (mutant)
3cu1 – hFGFR2 LBD D2 + hFGF1
2fdb – hFGFR2 LBD D2,D3 + hFGF8b
1nun – hFGFR2 LBD D2,D3 + hFGF10

FGFR3FGFR3

3grw – hFGFR3 LBD D2,D3 + antibody

FGFR3 complex with FGF

1ry7 – hFGFR3 LBD + hFGF1