G1SecL05
LA-2 FAB with OspA ComplexLA-2 FAB with OspA Complex
CONTENT
1. Background
2. Introduction to the fab complex, LA-2 , some history, what is it etc?
3. Structural capabilities – loops – loop 1, loop 2, loop 3 brief overview s and exactly how does the ospA bind to the LA-2
4. Variability – highlight Ala 208, trp 216, a hvl 217 -237 – basically our stories , a couple of sentences on each.
Background
Lyme disease, discovered in 1975, is a vector- borne disease caused by the inoculation of spirochete borrelia into the skin by members of hard bodied ticks of the family Ixodidae. Symptoms include arthritis at major joints, neurological problems such as reduced memory and poor ability to concentrate, and characteristic lesions erythema migans, more commonly known as the bull’s eye rash. A major outer surface membrane protein of Borrelia, ospA, plays a key role in immunity against Lyme disease through its binding to the antibody LA-2 fab.
Introduction to the LA-2 OspA
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