1xr7
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Crystal structure of RNA-dependent RNA Polymerase 3D from human rhinovirus serotype 16
OverviewOverview
Human rhinoviruses (HRV), the predominant members of the Picornaviridae, family of positive-strand RNA viruses, are the major causative agents of, the common cold. Given the lack of effective treatments for rhinoviral, infections, virally encoded proteins have become attractive therapeutic, targets. The HRV genome encodes an RNA-dependent RNA polymerase (RdRp), denoted 3Dpol, which is responsible for replicating the viral genome and, for synthesizing a protein primer used in the replication. Here the, crystal structures for three viral serotypes (1B, 14, and 16) of HRV 3Dpol, have been determined. The three structures are very similar to one, another, and to the closely related poliovirus (PV) 3Dpol enzyme. Because, the reported PV crystal structure shows significant disorder, HRV 3Dpol, provides the first complete view of a picornaviral RdRp. The folding, topology of HRV 3Dpol also resembles that of RdRps from hepatitis C virus, (HCV) and rabbit hemorrhagic disease virus (RHDV) despite very low, sequence homology.
About this StructureAbout this Structure
1XR7 is a Single protein structure of sequence from Human rhinovirus 2. This structure superseeds the now removed PDB entry 1TE9. Active as RNA-directed RNA polymerase, with EC number 2.7.7.48 Full crystallographic information is available from OCA.
ReferenceReference
The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy., Love RA, Maegley KA, Yu X, Ferre RA, Lingardo LK, Diehl W, Parge HE, Dragovich PS, Fuhrman SA, Structure. 2004 Aug;12(8):1533-44. PMID:15296746
Page seeded by OCA on Wed Nov 21 06:16:58 2007