1u09
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Footand Mouth Disease Virus RNA-dependent RNA polymerase
OverviewOverview
Genome replication in picornaviruses is catalyzed by a virally encoded, RNA-dependent RNA polymerase, termed 3D. The enzyme performs this, operation, together with other viral and probably host proteins, in the, cytoplasm of their host cells. The crystal structure of the 3D polymerase, of foot-and-mouth disease virus, one of the most important animal, pathogens, has been determined unliganded and bound to a template-primer, RNA decanucleotide. The enzyme folds in the characteristic fingers, palm, and thumb subdomains, with the presence of an NH2-terminal segment that, encircles the active site. In the complex, several conserved amino acid, side chains bind to the template-primer, likely mediating the initiation, of RNA synthesis. The structure provides essential information for studies, on RNA replication and the design of antiviral compounds.
About this StructureAbout this Structure
1U09 is a Protein complex structure of sequences from Foot-and-mouth disease virus. Active as RNA-directed RNA polymerase, with EC number 2.7.7.48 Full crystallographic information is available from OCA.
ReferenceReference
Structure of foot-and-mouth disease virus RNA-dependent RNA polymerase and its complex with a template-primer RNA., Ferrer-Orta C, Arias A, Perez-Luque R, Escarmis C, Domingo E, Verdaguer N, J Biol Chem. 2004 Nov 5;279(45):47212-21. Epub 2004 Aug 3. PMID:15294895
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