1sty
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THE ALPHA ANEURISM: A STRUCTURAL MOTIF REVEALED IN AN INSERTION MUTANT OF STAPHYLOCOCCAL NUCLEASE
OverviewOverview
The x-ray crystal structure of a mutant of staphylococcal nuclease that, contains a single glycine residue inserted in the C-terminal alpha-helix, has been solved to 1.67 A resolution and refined to a crystallographic R, value of 0.170. This inserted glycine residue is accommodated in the, alpha-helix by formation of a previously uncharacterized bulge, which we, term the alpha aneurism. A conformational search of known protein, structures has identified the alpha aneurism in a number of protein, families, including the histocompatibility antigens and hemoglobins.
About this StructureAbout this Structure
1STY is a Single protein structure of sequence from Staphylococcus aureus with CA and THP as ligands. Active as Micrococcal nuclease, with EC number 3.1.31.1 Full crystallographic information is available from OCA.
ReferenceReference
The alpha aneurism: a structural motif revealed in an insertion mutant of staphylococcal nuclease., Keefe LJ, Sondek J, Shortle D, Lattman EE, Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3275-9. PMID:8475069
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