1gi0
A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITEA NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE
Template:ABSTRACT PUBMED 11292354
About this StructureAbout this Structure
1gi0 is a 1 chain structure of Trypsin with sequence from Bos taurus. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. J Mol Biol. 2001 Apr 13;307(5):1451-86. PMID:11292354 doi:http://dx.doi.org/10.1006/jmbi.2001.4516
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OCACategories:
- Pages with broken file links
- Bos taurus
- Trypsin
- Elrod, K.
- Hatayte, J.
- Janc, J.
- Katz, B A.
- Link, J.
- Litvak, J.
- Luong, C.
- Mackman, R L.
- Rai, R.
- Rice, K.
- Rice, M.
- Sideris, S.
- Spencer, J.
- Sprengeler, P A.
- Verner, E.
- Young, W.
- Hydrolase
- Oxyanion hole water
- Shift of pka of his57
- Specificity
- Structure-based drug design
- Three-centered
- Thrombin
- Urokinase
- Very short hydrogen bond
- Zn+2-mediated inhibition