Molecular Playground/4'-PHOSPHOPANTETHEINYL TRANSFERASE (Sfp)

4'-PHOSPHOPANTETHEINYL TRANSFERASE SFP4'-PHOSPHOPANTETHEINYL TRANSFERASE SFP

Sfp is a 4'-phosphopantetheinyl transferase endogenous to B. Subtilis, first crystallized in 1999 [1]. The function of Sfp is transfer a phosphopantetheinyl group from coenzyme-A (CoA-SH) (spacefill) to the serine residue of peptides containing the sequence "DSL". Frequently this sequence is found in acyl- or peptidyl-carrier proteins in fatty acid synthases (FASs), polyketide synthases (PKSs), and nonribosomal peptide synthetases (NRPSs). This converts the inactive apo form peptide to the active holo form. Sfp fr

spinqualitylabelsall models Structure of HMG-CoA reductase (PDB entry 1dq8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image