1jpp
The Structure of a beta-Catenin Binding Repeat from Adenomatous Polyposis Coli (APC) in Complex with beta-Catenin
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OverviewOverview
The adenomatous polyposis coli (APC) tumor suppressor protein plays a, critical role in regulating cellular levels of the oncogene product, beta-catenin. APC binds to beta-catenin through a series of homologous 15, and 20 amino acid repeats. We have determined the crystal structure of a, 15 amino acid beta-catenin binding repeat from APC bound to the armadillo, repeat region of beta-catenin. Although it lacks significant sequence, homology, the N-terminal half of the repeat binds in a manner similar to, portions of E-cadherin and XTcf3, but the remaining interactions are, unique to APC. We discuss the implications of this new structure for the, design of therapeutics, and present evidence from structural, biochemical, and sequence data, which suggest that the 20 amino acid repeats can adopt, two modes of binding to beta-catenin.
DiseaseDisease
Known diseases associated with this structure: Adenoma, periampullary OMIM:[175100], Adenomatous polyposis coli OMIM:[175100], Adenomatous polyposis coli, attenuated OMIM:[175100], Colorectal cancer OMIM:[175100], Desmoid disease, hereditary OMIM:[175100], Gardner syndrome OMIM:[175100], Gastric cancer OMIM:[175100], Turcot syndrome OMIM:[175100]
About this StructureAbout this Structure
1JPP is a Protein complex structure of sequences from Mus musculus with GOL as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex., Eklof Spink K, Fridman SG, Weis WI, EMBO J. 2001 Nov 15;20(22):6203-12. PMID:11707392
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