1gs0
CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF MURINE POLY (ADP-RIBOSE) POLYMERASE-2
|
OverviewOverview
Poly(ADP-ribose) polymerase-1 (PARP-1) has become an important, pharmacological target in the treatment of cancer due to its cellular role, as a 'DNA-strand break sensor', which leads in part to resistance to some, existing chemo- and radiological treatments. Inhibitors have now been, developed which prevent PARP-1 from synthesizing poly(ADP-ribose) in, response to DNA-breaks and potentiate the cytotoxicity of DNA damaging, agents. However, with the recent discoveries of PARP-2, which has a, similar DNA-damage dependent catalytic activity, and additional members, containing the 'PARP catalytic' signature, the isoform selectivity and, resultant pharmacological effects of existing inhibitors are brought into, question. We present here the crystal structure of the catalytic fragment, of murine PARP-2, at 2.8 A resolution, and compare this to the catalytic, fragment of PARP-1, with an emphasis on providing a possible framework for, rational drug design in order to develop future isoform-specific, inhibitors.
About this StructureAbout this Structure
1GS0 is a Single protein structure of sequence from Mus musculus. Active as NAD(+) ADP-ribosyltransferase, with EC number 2.4.2.30 Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2., Oliver AW, Ame JC, Roe SM, Good V, de Murcia G, Pearl LH, Nucleic Acids Res. 2004 Jan 22;32(2):456-64. Print 2004. PMID:14739238
Page seeded by OCA on Tue Nov 20 16:15:38 2007