3br9
Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone InhibitorCrystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor
Template:ABSTRACT PUBMED 18242088
About this StructureAbout this Structure
3BR9 is a 2 chains structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.
ReferenceReference
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5- hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine., Zhou Y, Webber SE, Murphy DE, Li LS, Dragovich PS, Tran CV, Sun Z, Ruebsam F, Shah AM, Tsan M, Showalter RE, Patel R, Li B, Zhao Q, Han Q, Hermann T, Kissinger CR, Lebrun L, Sergeeva MV, Kirkovsky L, Bioorg Med Chem Lett. 2008 Feb 15;18(4):1413-8. Epub 2008 Jan 8. PMID:18242088
Page seeded by OCA on Wed Dec 24 11:29:09 2008
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OCACategories:
- Pages with broken file links
- Hepatitis c virus
- RNA-directed RNA polymerase
- Han, Q.
- Kissinger, C R.
- Showalter, R E.
- Zhao, Q.
- Antiviral
- Cytoplasm
- Host-virus interaction
- Hydrolase
- Metal-binding
- Nucleotide-binding
- Nucleotidyltransferase
- Protein-ligand complex
- Ribonucleoprotein
- Rna replication
- Rna-binding
- Rna-directed rna polymerase
- Transcription
- Transcription regulation
- Transferase
- Viral nucleoprotein