1fin
CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
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OverviewOverview
The crystal structure of the human cyclinA-cyclin-dependent kinase2, (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds, to one side of CDK2's catalytic cleft, inducing large conformational, changes in its PSTAIRE helix and T-loop. These changes activate the kinase, by realigning active site residues and relieving the steric blockade at, the entrance of the catalytic cleft.
About this StructureAbout this Structure
1FIN is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:7630397
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