1es7
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COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS
OverviewOverview
Bone morphogenetic proteins (BMPs) belong to the large transforming growth, factor-beta (TGF-beta) superfamily of multifunctional cytokines. BMP-2 can, induce ectopic bone and cartilage formation in adult vertebrates and is, involved in central steps in early embryonal development in animals., Signaling by these cytokines requires binding of two types of, transmembrane serine/threonine receptor kinase chains classified as type I, and type II. Here we report the crystal structure of human dimeric BMP-2, in complex with two high affinity BMP receptor IA extracellular domains, (BRIAec). The receptor chains bind to the 'wrist' epitopes of the BMP-2, dimer and contact both BMP-2 monomers. No contacts exist between the, receptor domains. The model reveals the structural basis for, discrimination between type I and type II receptors and the variability of, receptor-ligand interactions that is seen in BMP-TGF-beta systems.
DiseaseDisease
Known diseases associated with this structure: Cowden-like syndrome OMIM:[601299], Juvenile polyposis syndrome, infantile form OMIM:[601299], Polyposis syndrome, hereditary mixed, 2 OMIM:[601299], Polyposis, juvenile intestinal OMIM:[601299]
About this StructureAbout this Structure
1ES7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the BMP-2-BRIA ectodomain complex., Kirsch T, Sebald W, Dreyer MK, Nat Struct Biol. 2000 Jun;7(6):492-6. PMID:10881198
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