1aoo
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AG-SUBSTITUTED METALLOTHIONEIN FROM SACCHAROMYCES CEREVISIAE, NMR, MINIMIZED AVERAGE STRUCTURE
OverviewOverview
3D solution structural calculations for yeast silver(I)-substituted, metallothionein (MT) and native copper(I) MT were completed using, experimentally determined NOE and dihedral angle constraints, in, conjunction with experimentally derived metal-to-Cys connectivities for, AgMT which were assumed identical for CuMT. For the first 40 residues in, both structures, the polypeptide backbone wraps around the metal cluster, in two large parallel loops separated by a deep cleft containing the metal, cluster. Minor differences between the two structures include differences, in hydrogen bonds and the orientation of the N-terminus with the overall, protein volume conserved to within 6.5%.
About this StructureAbout this Structure
1AOO is a Single protein structure of sequence from Saccharomyces cerevisiae with AG as ligand. Full crystallographic information is available from OCA.
ReferenceReference
3D solution structure of copper and silver-substituted yeast metallothioneins., Peterson CW, Narula SS, Armitage IM, FEBS Lett. 1996 Jan 22;379(1):85-93. PMID:8566237
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