1w0y
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TF7A_3771 COMPLEX
OverviewOverview
Proof of concept experiments have shown that tissue factor/factor VIIa, inhibitors have antithrombotic activity without enhancing bleeding, propensity. Starting from lead compounds generated by a biased, combinatorial approach, phenylglycine amide tissue factor/factor VIIa, inhibitors with low nanomolar affinity and good selectivity against other, serine proteases of the coagulation cascade were designed, using the, guidance of X-ray structural analysis and molecular modelling.
About this StructureAbout this Structure
1W0Y is a [Protein complex] structure of sequences from [Homo sapiens] with FUC, BGC, CA, CAC and 771 as [ligands]. Active as [[1]], with EC number [3.4.21.21]. Full crystallographic information is available from [OCA].
ReferenceReference
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors., Groebke Zbinden K, Banner DW, Ackermann J, D'Arcy A, Kirchhofer D, Ji YH, Tschopp TB, Wallbaum S, Weber L, Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. PMID:15664864
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OCA- Pages with broken file links
- Homo sapiens
- Protein complex
- Ackermann, J.
- Arcy, A.D.
- Banner, D.W.
- Groebke-Zbinden, K.
- Ji, Y.H.
- Kirchhofer, D.
- Tschopp, T.B.
- Wallbaum, S.
- Weber, L.
- 771
- BGC
- CA
- CAC
- FUC
- Blood coagulation
- Calcium-binding
- Co-factor
- Coagulation
- Enzyme complex
- Gamma-carboxyglutamic acid
- Glycoprotein
- Hydrolase
- Plasma
- Serine protease
- Vitamin k