1a6y
REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX
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OverviewOverview
The nuclear hormone receptors form the largest known family of, transcription factors. The current notion of receptor DNA discrimination, based solely on one major type of hexameric half-site and a highly, conserved 66-residue core DNA-binding domain (DBD), does not adequately, describe how more than 150 nonsteroid receptors differentiate among, response elements. Here, we describe the 2.3 A crystal structure of the, DNA-binding region of the orphan receptor RevErb arranged as a tandem, homodimer on its optimal response element. The structure reveals the, presence of a second major protein-DNA interface adjacent to the classical, one involving the half-sites. A sequence comparison of orphan receptors, suggests that unique minor-groove interactions involving the receptor, hinge regions impart the necessary DNA and dimerization specificity.
About this StructureAbout this Structure
1A6Y is a Single protein structure of sequence from Homo sapiens with ZN as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Structural elements of an orphan nuclear receptor-DNA complex., Zhao Q, Khorasanizadeh S, Miyoshi Y, Lazar MA, Rastinejad F, Mol Cell. 1998 May;1(6):849-61. PMID:9660968
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