Prolyl hydroxylase domain

Template:STRUCTURE 3hqu

Prolyl hydroxylase domain (PHD) proteins mediate oxygen-dependent degradation of Hypoxia-inducible factor (HIF) α subunit. They include PHD1, PHD2 and PHD3. The PHD is a Fe+2/oxogluterate (2OG)-dependent enzyme. For more detalis see Molecular Playground/Prolyl Hydroxylase Domain (PHD) Enzyme.

3D Structures of prolyl hydroxylase domain3D Structures of prolyl hydroxylase domain

2y33 – hPHD2 catalytic domain + Zn + chloro-iodoisoquinolin-carbonyl glycine – human
2y34 - hPHD2 catalytic domain + Fe + chloro-iodoisoquinolin-carbonyl glycine
3ouh, 3oui - hPHD2 catalytic domain + Fe + inhibitor
3ouj - hPHD2 catalytic domain + Fe + 2OG
3hqr - hPHD2 catalytic domain (mutant) + Mn + HIF 1 α C terminal + oxalylglycine
3hqu - hPHD2 catalytic domain + Fe + HIF 1 α C terminal + chloro-iodoisoquinolin-carbonyl glycine
2hbt, 2hbu - hPHD2 catalytic domain + Fe + chloro-iodoisoquinolin-carbonyl glycine
2g19, 2g1m - hPHD2 catalytic domain + Fe + hydroxy-iodoisoquinolin-carbonyl glycine

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Michal Harel, Alexander Berchansky, Joel L. Sussman