Im3

is the Colicin Immunity Protein produced by E. coli cells alongside Colicin E3 to prevent the Colicin's RNase activity from killing the cell. Once the complex has been released by the producing E. coli it then binds to a target cell, and upon binding the immunity protein is released from the cytotoxic domain.

1jch, resolution 3.02Å ()

Ligands:

,

Related:

3eip, 1e44

Structural annotation:
Resources:	CATH : 1Jchb00, 1Jchd00 InterPro : Ipr009105, Ipr003058, Ipr003063 Pfam : PF03515, PF09000, PF03513 SCOP : d1jcha3, d1jcha2, d1jcha1, d1jchb_, d1jchc2, d1jchc3, d1jchc1, d1jchd_ UniProt : P00646, P02984

Functional annotation:
Cellular component:	extrachromosomal circular DNA
Biological process:	pathogenesis cytolysis defense response to bacterium bacteriocin immunity
Molecular function:	nucleic acid binding ribosome binding receptor binding nuclease activity endonuclease activity hydrolase activity hydrolase activity, acting on ester bonds RNA binding protein binding toxin binding

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

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Gemma McGoldrick, Michal Harel