2j0b
STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE IN COMPLEX WITH UDP AND MANGANESE
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OverviewOverview
Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modify, Notch receptors, altering their ligand-binding specificity to regulate, Notch signaling in development. We present the crystal structure of mouse, Manic Fringe bound to UDP and manganese. The structure reveals amino acid, residues involved in recognition of donor substrates and catalysis, and a, putative binding pocket for acceptor substrates. Mutations of several, invariant residues in this pocket impair Fringe activity in vivo.
About this StructureAbout this Structure
2J0B is a [Single protein] structure of sequence from [Mus musculus] with SO4, K, MN and UDP as [ligands]. Active as [[1]], with EC number [2.4.1.222]. Full crystallographic information is available from [OCA].
ReferenceReference
Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:16964258
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