Naproxen

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NaproxenNaproxen

Naproxen Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that can be prescribed to relieve swelling, stiffness, tenderness, or pain that can be caused by:[1]

  • osteoarthritis
  • rheumatoid arthritis
  • juvenile arthritis
  • ankylosing spondylitis
  • bursitis
  • tendinitis
  • gouty arthritis

Readily available over the counter, naproxen is also used to treat:[2]

  • headaches
  • menstrual pain
  • common colds
  • toothaches
  • muscle ache
  • back pain

"Naproxen and naproxen sodium are marketed under various trade names, including: Aleve, Anaprox, Antalgin, Feminax Ultra, Flanax, Inza, Midol Extended Relief, Miranax, Nalgesin, Naposin, Naprelan, Naprogesic, Naprosyn, Narocin, Proxen, Synflex and Xenobid."[3] Like other NSAID medications naproxen is known to cause ulcers, bleeding, or holes in the lining of the stomach and intestines and should always be taken with a glass of water.

Some of naproxen's side effects, are and are not limited too: constipation, diarrhea, sores in mouth, excessive thirst, headache, dizziness, drowsiness, ringing in the ears, hearing problems. More severe symptoms such as blisters, changes in vision, rash, hives, difficulty breathing, flu-like symptoms, bloody urine, and stomach pain are also known to occur.[4]

Chemical PropertiesChemical Properties

IUPAC:(+)-(S)-2-(6-methoxynaphthalen-2-yl)propanoic acid

Molecular Weight:230.250 g/mol

Chemical Formula: C14O3H14

SynthesisSynthesis

[5]

AdministrationAdministration

Prescription naproxen comes in tablet form as an extended-release, delayed-release, or liquid suspension pill that can be taken by mouth. Due to side effects is is commonly advised that it is taken with a full glass of water, taking the tablet with milk or food has also been known to prevent nausea, a common side effect. Pills should always be taken whole, never crushed, chewed, or split.

COX-1 & COX-2 InhibitorCOX-1 & COX-2 Inhibitor

Cyclooxygenase abbreviated as COX

Naproxen In VivoNaproxen In Vivo

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ReferencesReferences

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Student, David Canner, Karsten Theis, Alexander Berchansky