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Sandbox6 Eric Martz

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Please do not edit this page. Eric Martz, February 2011.


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  • Homology model of 83-341 on template chain A of 3e4c, 52% sequence identity ().
 Amino Terminus                 Carboxy Terminus 
  • .
  • The seems unremarkable. Bear in mind that sidechain positions are incorrect in a homology model.

Anionic (-) / Cationic (+)

  • The inner face of 95-140 is . Bear in mind that sidechain positions are incorrect in a homology model. . The distribution of hydrophobic residues in 83-140 of the homology model is similar to that in the .


  • The inner face of 95-140 is , even based upon a multiple sequence alignment that includes mostly caspases other than 12[1] .

  • When the multiple sequence alignment is limited to the 14 caspase-12 sequences available from Uniprot (APD 0.30), most of the residues have insufficient data, but a few on the outside face are highly conserved, namely

The homology model can be downloaded from homology-model-83-341.

  1. ↑ ConSurf run using 80 sequences from the Uniref-90 sequence database. APD 0.94.

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Eric Martz
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