Sorafenib

Tyrosine Kinase Inhibitor Pharmacokinetics
	VEGFR & KIT Inhibitors		EGFR Inhibitors			BCR-Abl Inhibitor
Parameter	Sunitinib (Sutent)	Sorafenib (Nexavar)	Erlotinib (Tarceva)	Gefitinib (Iressa)	Lapatinib (Tykerb)	Imatinib (Gleevec)	Nilotinib (Tasigna)	Dasatinib (Sprycel)
T_max (hr)	8	8.3	2.0	5.4	4	3.7	3.0	1.0
C_max (ng/ml)	24.6	460	69.6	130	115	2070	411	124
Bioavailability (%)	Variable	29-49	99	59	Variable	98	30	20
Protein Binding (%)	95	99	93	90	99	95	98	96
T_1/2 (hr)	83	29	9.4	26.9	9.6	26.6	16.0	3.3
AUC (ng/ml/hr)	1921	11040	20577	3850	1429	4760	10052	461
Dosage (mg)	50	50	150	250	100	400	200	200
Metabolism	Hepatic (CYP3A4)	Hepatic (CYP3A4)	Hepatic (CYP3A4)	Hepatic (CYP3A4)	Hepatic (CYP3A4)	Hepatic (CYP3A4)	Hepatic (CYP3A4)	Hepatic (CYP3A4)

For Pharmacokinetic Data References, see: References

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