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CDK Inhibitor p19INK4dCDK Inhibitor p19INK4d

spinqualitylabelsall models PDB ID 1bd8 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1bd8, resolution 1.80Å ()
Structural annotation: Resources: CATH : 1Bd8000 InterPro : Ipr002110 Pfam : PF00023 SCOP : d1bd8__ UniProt : P55273
Functional annotation: Cellular component: cytoplasm nucleus Biological process: regulation of cyclin-dependent protein kinase activity negative regulation of cell cycle cell cycle arrest cell cycle negative regulation of cell proliferation sensory perception of sound Molecular function: cyclin-dependent protein kinase inhibitor activity protein binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

p19INK4d in the Cell Cyclep19INK4d in the Cell Cycle

CDK Inhibitor p19INK4d is a cyclin-dependent kinase (CDK) inhibitor in the INK4 family of CDK inhibitors, which includes p16INK4a, p15INK4b,and p18INK4c. Progression through the G1 phase of the cell cycle and subsequent entry into the S phase depend on the phosphorylating effects of CDK4 and CDK6. These two CDKs must form cyclin-CDK complexes to phosphorylate the retinoblastoma protein, inhibiting its growth-suppressing function, and triggering an E2F-dependent transcriptional program necessary for entry into S phase. The INK4 family members specifically bind to CDK4 and CDK6, inhibiting cyclin-CDK complexation and obstructing the progression of G1 phase.

To view p19INK4d bound to CDK6, click here:

p19INK4d Structurep19INK4d Structure

The four INK4 proteins share a similar sturcture consisting of either four (p15 & p16) or five (p18 and p19) ankyrin repeats (AR).

ReferencesReferences

[1] Barrick D. (2009). Biological Regulation via Ankyrin Repeat Folding. Acs Chemical Biology 4,19-22.

[2] Brotherton DH, Dhanaraj V, Wick S, Brizuela L, Domaille PJ, Volyanik E, Xu X, Parisini E, Smith BO, Archer SJ and others. (1998). Crystal structure of the complex of the cyclin D dependent kinase Cdk6 bound to the cell-cycle inhibitor p19(INK4d). Nature 395,244-250.

[3] Ceruti JM, Scassa ME, Flo JM, Varone CL, Canepa ET. (2005). Induction of p19INK4d in response to ultraviolet light improves DNA repair and confers resistance to apoptosis in neuroblastoma cells. Oncogene 24,4065-4080.

[4] Low C, Homeyer N, Weininger U, Sticht H, Balbach J. (2009). Conformational Switch upon Phosphorylation: Human CDK Inhibitor p19(INK4d) between the Native and Partially Folded State. Acs Chemical Biology 4,53-63.

[5] Thullberg M, Bartek J, Lukas J. (2000). Ubiquitin/proteasome-mediated degradation of p19(INK4d) determines its periodic expression during the cell cycle. Oncogene 19,2870-2876.