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Sandbox Eric Martz

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At right is a morph[1][2] from a Cullin-RING complex to the same complex after NEDD8ylation (covalent addition of the NEDD8 ubiquitin-like chain to LysXXX of Cullin). NEDD8 binds and rotates the C-terminal domain of cullin, releasing the folded RING domain from its binding site. RING remains attached to Cullin by a coil at the RING X-terminus which is embedded in Cullin.

Notes and ReferencesNotes and References

  1. ↑ File:3dpl 3dqv acr morph.pdb
  2. ↑ Methods

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Eric Martz
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