3ran

CANINE GDP-RAN Q69L MUTANTCANINE GDP-RAN Q69L MUTANT

FunctionFunction

[RAN_CANFA] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity).

About this StructureAbout this Structure

3ran is a 4 chain structure with sequence from Canis lupus familiaris. Full crystallographic information is available from OCA.

ReferenceReference

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↑ Stewart M, Kent HM, McCoy AJ. The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2). J Mol Biol. 1998 Dec 18;284(5):1517-27. PMID:9878368 doi:10.1006/jmbi.1998.2204

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OCA

[1] Stewart M, Kent HM, McCoy AJ. The structure of the Q69L mutant of GDP-Ran shows a major conformational change in the switch II loop that accounts for its failure to bind nuclear transport factor 2 (NTF2). J Mol Biol. 1998 Dec 18;284(5):1517-27. PMID:9878368 doi:10.1006/jmbi.1998.2204

[xtra 1]