1n15
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FOLLOWING THE C HEME REDUCTION IN NITRITE REDUCTASE FROM PSEUDOMONAS AERUGINOSA
OverviewOverview
The structures of nitrite reductase from Paracoccus denitrificans GB17, (NiR-Pd) and Pseudomonas aeruginosa (NiR-Pa) have been described for the, oxidized and reduced state (Fulop, V., Moir, J. W. B., Ferguson, S. J., and Hajdu, J. (1995) Cell 81, 369-377; Nurizzo, D., Silvestrini, M. C., Mathieu, M., Cutruzzola, F., Bourgeois, D., Fulop, V., Hajdu, J., Brunori, M., Tegoni, M., and Cambillau, C. (1997) Structure 5, 1157-1171; Nurizzo, D., Cutruzzola, F., Arese, M., Bourgeois, D., Brunori, M., Cambillau, C. , and Tegoni, M. (1998) Biochemistry 37, 13987-13996). Major conformational, rearrangements are observed in the extreme states although they are more, substantial in NiR-Pd. The four structures differ significantly in the c, heme domains. Upon reduction, a His17/Met106 heme-ligand ... [(full description)]
About this StructureAbout this Structure
1N15 is a [Single protein] structure of sequence from [Pseudomonas aeruginosa] with HEC and DHE as [ligands]. Active as [Transferred entry: 1.7.2.1], with EC number [1.9.3.2]. Structure known Active Sites: NIA and NIB. Full crystallographic information is available from [OCA].
ReferenceReference
Does the reduction of c heme trigger the conformational change of crystalline nitrite reductase?, Nurizzo D, Cutruzzola F, Arese M, Bourgeois D, Brunori M, Cambillau C, Tegoni M, J Biol Chem. 1999 May 21;274(21):14997-5004. PMID:10329702
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