1w1h

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File:1w1h.png

1w1h, resolution 1.45Å ()

Ligands:

,

Activity:

Non-specific serine/threonine protein kinase, with EC number 2.7.11.1

Related:

1h1w, 1oky, 1okz, 1uu3, 1uu7, 1uu8, 1uu9, 1uvr, 1w1d, 1w1g

Structural annotation:
Resources:	CATH : 1W1Ha00, 1W1Hb00, 1W1Hc00, 1W1Hd00 InterPro : Ipr011993, Ipr015746, Ipr011009, Ipr002290, Ipr000719, Ipr001849, Ipr008271 UniProt : O15530

Functional annotation:
Cellular component:	membrane plasma membrane cytoplasm
Biological process:	insulin receptor signaling pathway intracellular signaling cascade protein amino acid phosphorylation actin cytoskeleton organization and biogenesis
Molecular function:	protein serine/threonine kinase activity protein kinase activity protein binding ATP binding kinase activity transferase activity nucleotide binding 3-phosphoinositide-dependent protein kinase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAINCRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN

Template:ABSTRACT PUBMED 15457207

About this StructureAbout this Structure

1W1H is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Komander D, Fairservice A, Deak M, Kular GS, Prescott AR, Peter Downes C, Safrany ST, Alessi DR, van Aalten DM. Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J. 2004 Oct 13;23(20):3918-28. Epub 2004 Sep 30. PMID:15457207 doi:10.1038/sj.emboj.7600379

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OCA

[1] Komander D, Fairservice A, Deak M, Kular GS, Prescott AR, Peter Downes C, Safrany ST, Alessi DR, van Aalten DM. Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates. EMBO J. 2004 Oct 13;23(20):3918-28. Epub 2004 Sep 30. PMID:15457207 doi:10.1038/sj.emboj.7600379

[xtra 1]