2nnx

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Template:STRUCTURE 2nnx

File:2nnx.png

Crystal Structure of the H46R, H48Q double mutant of human [Cu-Zn] Superoxide DismutaseCrystal Structure of the H46R, H48Q double mutant of human [Cu-Zn] Superoxide Dismutase

Template:ABSTRACT PUBMED 17092942

DiseaseDisease

Known disease associated with this structure: Amyotrophic lateral sclerosis, due to SOD1 deficiency OMIM:[147450]

About this StructureAbout this Structure

2NNX is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Wang J, Caruano-Yzermans A, Rodriguez A, Scheurmann JP, Slunt HH, Cao X, Gitlin J, Hart PJ, Borchelt DR. Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability. J Biol Chem. 2007 Jan 5;282(1):345-52. Epub 2006 Nov 8. PMID:17092942 doi:10.1074/jbc.M604503200

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OCA

[1] Wang J, Caruano-Yzermans A, Rodriguez A, Scheurmann JP, Slunt HH, Cao X, Gitlin J, Hart PJ, Borchelt DR. Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability. J Biol Chem. 2007 Jan 5;282(1):345-52. Epub 2006 Nov 8. PMID:17092942 doi:10.1074/jbc.M604503200

[xtra 1]