1cdd
STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE
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OverviewOverview
The three-dimensional structure of phosphoribosylglycinamide formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at 2.8-A resolution and as a ternary complex with the substrate glycinamide ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure is a modified doubly wound alpha/beta sheet with flexibility in the active site, including a disordered loop in the apo structure, which is ordered in the ternary complex structure. This enzyme is a target for anti-cancer therapy and now for structure-based drug design.
About this StructureAbout this Structure
1CDD is a Single protein structure of sequence from Escherichia coli with as ligand. Active as Phosphoribosylglycinamide formyltransferase, with EC number 2.1.2.2 Full crystallographic information is available from OCA.
ReferenceReference
Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase., Almassy RJ, Janson CA, Kan CC, Hostomska Z, Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6114-8. PMID:1631098
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