2hz4

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Template:STRUCTURE 2hz4

File:2hz4.png

Abl kinase domain unligated and in complex with tetrahydrostaurosporineAbl kinase domain unligated and in complex with tetrahydrostaurosporine

Template:ABSTRACT PUBMED 17164530

DiseaseDisease

Known disease associated with this structure: Leukemia, Philadelphia chromosome-positive, resistant to imatinib OMIM:[189980]

About this StructureAbout this Structure

2HZ4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia., Cowan-Jacob SW, Fendrich G, Floersheimer A, Furet P, Liebetanz J, Rummel G, Rheinberger P, Centeleghe M, Fabbro D, Manley PW, Acta Crystallogr D Biol Crystallogr. 2007 Jan;63(Pt 1):80-93. Epub 2006, Dec 13. PMID:17164530

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