2fir

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Template:ABSTRACT PUBMED 16757484

File:2fir.png

2fir, resolution 2.00Å ()

Ligands:

, , , , , , ,

Non-Standard Residues:

Gene:

F7 (Homo sapiens), F3 (Homo sapiens)

Activity:

Coagulation factor VIIa, with EC number 3.4.21.21

Related:

1dan, 2a2q, 2aer, 2b8o

Structural annotation:
Resources:	CATH : 2Firh02, 2Firh01, 2Firt02, 2Firt01 InterPro : Ipr001314, Ipr018114, Ipr001254, Ipr000742, Ipr000294, Ipr000152, Ipr018097, Ipr017857, Ipr013032, Ipr012224, Ipr009003, Ipr001881, Ipr016354, Ipr015373, Ipr013783, Ipr003961, Ipr001187 Pfam : PF00089, PF00008, PF00594, PF09294, PF01108 SCOP : d2firh1, d2firl1, d2firl3, d2firl2, d2firt1, d2firt2

Evolutionary conservation:

Toggle Conservation Colors:

Rows = identical sequences:

Further Information:

Caveats,

Explanation,
Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Crystal structure of DFPR-VIIa/sTFCrystal structure of DFPR-VIIa/sTF

DiseaseDisease

Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this StructureAbout this Structure

2FIR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa., Bajaj SP, Schmidt AE, Agah S, Bajaj MS, Padmanabhan K, J Biol Chem. 2006 Aug 25;281(34):24873-88. Epub 2006 Jun 6. PMID:16757484

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