8k0d

Cryo-EM structure of conformation 2 of complex of Nipah virus attachment G with 1E5 neutralizing antibodyCryo-EM structure of conformation 2 of complex of Nipah virus attachment G with 1E5 neutralizing antibody

Structural highlights

8k0d is a 6 chain structure with sequence from Henipavirus nipahense and Macaca mulatta. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.94Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLYCP_NIPAV Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.^[1] ^[2]

References

↑ Diederich S, Maisner A. Molecular characteristics of the Nipah virus glycoproteins. Ann N Y Acad Sci. 2007 Apr;1102:39-50. PMID:17470910 doi:http://dx.doi.org/10.1196/annals.1408.003
↑ Diederich S, Moll M, Klenk HD, Maisner A. The nipah virus fusion protein is cleaved within the endosomal compartment. J Biol Chem. 2005 Aug 19;280(33):29899-903. Epub 2005 Jun 16. PMID:15961384 doi:http://dx.doi.org/10.1074/jbc.M504598200

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OCA

[1] Diederich S, Maisner A. Molecular characteristics of the Nipah virus glycoproteins. Ann N Y Acad Sci. 2007 Apr;1102:39-50. PMID:17470910 doi:http://dx.doi.org/10.1196/annals.1408.003

[2] Diederich S, Moll M, Klenk HD, Maisner A. The nipah virus fusion protein is cleaved within the endosomal compartment. J Biol Chem. 2005 Aug 19;280(33):29899-903. Epub 2005 Jun 16. PMID:15961384 doi:http://dx.doi.org/10.1074/jbc.M504598200

[1]

[2]

8k0d

Cryo-EM structure of conformation 2 of complex of Nipah virus attachment G with 1E5 neutralizing antibodyCryo-EM structure of conformation 2 of complex of Nipah virus attachment G with 1E5 neutralizing antibody

Structural highlights

Function

References

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8k0d

Cryo-EM structure of conformation 2 of complex of Nipah virus attachment G with 1E5 neutralizing antibodyCryo-EM structure of conformation 2 of complex of Nipah virus attachment G with 1E5 neutralizing antibody

Structural highlights

Function

References

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