MAP kinase phosphatase

Function MAP kinase phosphatase (MKP) or Dual specificity phosphatase (DUSP) are phosphatases which reverse the activation of MAP kinases by dephosphorylating tyrosine or threonine residues. MKP-4 and MKP-5 are localized in the nucleus and cytosole MKP-6, MKP-7 and MKP-3 are localized in the nucleus Relevance DUSP is implicated in the initiation and development of cancer.

spinqualitylabelsall models MAP kinase phosphatase 3 (PDB code 1hzm) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of MAP kinase phosphatase3D Structures of MAP kinase phosphatase

Updated on 11-July-2024

3ezz – hMKP-2 (mutant) or DUSP-HVH2 - human
2hcm – mDUSP
1m3g – hMKP-PAC-1 catalytic domain (mutant) - NMR
2g6z – hMKP-3
1hzm - hMKP-3 or DUSP-5
1mkp - hMKP-3 or DUSP-5 (mutant)
3lj8 – hMKP-4
4jmk – hDUSP-8 (mutant)
2ouc, 2oud, 1zzw, 7y4c - hMKP-5 or DUSP-10
7y4b, 7y4d, 7y4e – hMKP-5 (mutant)
6mc1, 7u4o, 7u4r, 7umu, 7umv, 7un0, 7un4 – hMKP-5 + inhibitor
3tg1 – hMKP-5 + MAP kinase 14
4jmj – hDUSP-11 catalytic domain (mutant)
2wgp – hMKP-6 or DUSP-14
1yz4 – hDUSP-15 catalytic domain (mutant)
2vsw, 3tg3 - hMKP-7 or DUSP-16
4yr8 – hMKP-7 + MAPK8
4d3p, 4d3q, 4d3r – hDUSP-19 (mutant)
4woh – hDUSP-22 (mutant) + nitrophenolphosphate
2img – hDUSP-23 + malate
5gtj, 4b04, 4hrf – hDUSP-26 catalytic domain (mutant)